Coevolution at the proteome scale - Institute for Protein Design
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Today we report in Science the identification of hundreds of previously uncharacterized protein–protein interactions in E. coli and the pathogenic bacterium M. tuberculosis. These include both previously unknown protein complexes and previously uncharacterized components of known complexes. This research was led by postdoctoral fellow Qian Cong and included former Baker lab graduate student Sergey Ovchinnikov, now a John Harvard Distinguished Science
Novel machine learning approaches revolutionize protein knowledge: Trends in Biochemical Sciences
Coevolution-based prediction of key allosteric residues for protein function regulation
IPD Publication - Institute for Protein Design
Computed structures of core eukaryotic protein complexes
Deploying synthetic coevolution and machine learning to engineer protein- protein interactions
July, 2019 - Institute for Protein Design
News - Institute for Protein Design
Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences
News - Institute for Protein Design
Conservation of coevolving protein interfaces bridges prokaryote–eukaryote homologies in the twilight zone
Recent advances in predicting and modeling protein–protein interactions: Trends in Biochemical Sciences
Structural prediction of protein interactions and docking using conservation and coevolution - Andreani - 2020 - WIREs Computational Molecular Science - Wiley Online Library
Co-evolutionary landscape at the interface and non-interface regions of protein-protein interaction complexes - ScienceDirect
